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Background: Suboptimal diet is an important preventable risk factor for non-communicable diseases NCDs ; however, its impact on the burden of NCDs has not been systematically evaluated.

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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. Rare variant analysis of 6 new QT interval-associated loci in unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

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